Chloral hydrate
- CAS No. ：302-17-0
- Molecular Formula：C<sub>2</sub>H<sub>3</sub>Cl<sub>3</sub>O<sub>2</sub>
- Purity：
- Molecular Weight：165.404
Product Details
pd_meltingpoint:57 °C(lit.)
Appearance:colourless crystals with a pentrating odour
Buy reliable Quality Chloral hydrate(TCA) 302-17-0 raw material with Honest Price
1.What is the Chloral hydrate ?
Chloral is a combustible, oily liquid with a pungent irritating odor.
ChEBI: An organochlorine compound that is the hydrate of trichloroacetaldehyde.
Chloral hydrate is one of the oldest sedatives used for dental sedation. It was first synthesized in 1832 by Justus von Liebig and was the first synthetic central nervous system (CNS) depressant. It was used to treat delirium tremens, insomnia, and anxiety, although it is considered an unapproved drug by the US Food and Drug Administration. Initially considered to be a safer alternative to opium, it was noted to produce rapid unconsciousness when combined with ethanol. Physical dependence can occur with chronic use.Chloral hydrate is classified as a sedative-hypnotic and is known to induce sleep in children. It has been very popular in pediatric dentistry since the mid-1950s. Chloral hydrate is rapidly absorbed following oral administration and is converted through its first pass in the liver to trichloroethanol，its active form. Trichloroethanol is conjugated in the liver and excreted in the urine. Like other agents that are metabolized in the liver, chloral hydrate may interact with other drugs, herbs, or foods resulting in clinically significant alterations of the agents (e.g.,warfarin).
2.What is the CAS number for Chloral hydrate ?
The CAS number of Chloral hydrate is 302-17-0.
3.What are another words for Chloral hydrate ?
Synonyms for Chloral hydrate 302-17-0:Chloralhydrate (8CI);1,1,1-Trichloro-2,2-dihydroxyethane;2,2,2-Trichloro-1,1-ethanediol;Bi 3411;Chloral, monohydrate;Chloraldurat;TCA;
4.What is Chloral hydrate (302-17-0) used for?
Chloral hydrate is used as an intermediate in the production of insecticides, herbicides and hypnotic drugs. It has also been widely used as a sedative or hypnotic drug in humans at oral doses of up to about 750-1000 mg/day. Chloral hydrate is used as a sedative hypnotic, more commonly in pediatrics. With the advent of newer sedative hypnotics, its use has significantly decreased. It is also a drug of abuse, particularly in combination with ethanol to produce an amnestic effect in an individual who ingests it unknowingly.
InChI:InChI=1/C2HCl3O.H2O/c3-2(4,5)1-6;/h1H;1H2
Relevant articles related to Chloral hydrate:
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Kinetics and mechanistic investigation into the degradation of naproxen by a UV/chlorine process |
Gao, Yu-Qiong,Gao, Nai-Yun,Chu, Wen-Hai,Yang, Qin-Lin,Yin, Da-Qiang , p. 33627 - 33634 (2017) |
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Thermally induced oxidative decarboxylation of copper complexes of amino acids and formation of strecker aldehyde |
Nashalian, Ossanna,Yaylayan, Varoujan A. , p. 8518 - 8523 (2015/04/22) |
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Hydrolysis of N-(2,2,2-trichloroethyl)arenesulfonamides |
Rozentsveig,Levkovskaya,Mirskova,Kashik , p. 1760 - 1764 (2007/10/03) |
5.Buy Chloral hydrate with the best price .
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Chloral hydrate is a white crystalline solid with hypnotic and sedative effects, historically used as a hypnotic agent. The application of TCA in the pharmaceutical field has been limited due to its potential toxicity and addictive properties.
